Accelerated 3D T2 mapping with dictionary based matching for prostate imaging

Abstract

PURPOSE:To develop a fast and accurate method for 3D T2 mapping of prostate cancer using undersampled acquisition and dictionary-based fitting.METHODS:3D high-resolution T2 -weighted images (0.9 × 0.9 × 3 mm3 ) were obtained with a multishot T2 -prepared balanced steady-state free precession (T2 -prep-bSSFP) acquisition sequence using a 3D variable density undersampled Cartesian trajectory. Each T2 -weighted image was reconstructed using total variation regularized sensitivity encoding. A flexible simulation framework based on extended phase graphs generated a dictionary of magnetization signals, which was customized to the proposed sequence. The dictionary was matched to the acquired T2 -weighted images to retrieve quantitative T2 values, which were then compared to gold-standard spin echo acquisition values using monoexponential fitting. The proposed approach was validated in simulations and a T1 /T2 phantom, and feasibility was tested in 8 healthy subjects.RESULTS:The simulation analysis showed that the proposed T2 mapping approach is robust to noise and typically observed T1 variations. T2 values obtained in the phantom with T2 prep-bSSFP and the acquisition-specific, dictionary-based matching were highly correlated with the gold-standard spin echo method (r = 0.99). Furthermore, no differences were observed with the accelerated acquisition compared to the fully sampled acquisition (r = 0.99). T2 values obtained in prostate peripheral zone, central gland, and muscle in healthy subjects (age, 26 ± 6 years) were 97 ± 14, 76 ± 7, and 36 ± 3 ms, respectively.CONCLUSION:3D quantitative T2 mapping of the whole prostate can be achieved in 3 minutes.