Pontificia Universidad Católica de Chile Pontificia Universidad Católica de Chile
Nordio G., Henningsson M., Chiribiri A., Villa A.D.M., Schneider T. and Botnar R.M. (2017)

3D myocardial T1 mapping using saturation recovery

Revista : Journal of Magnetic Resonance Imaging
Volumen : 46
Número : 1
Páginas : 218-227
Tipo de publicación : ISI Ir a publicación


PURPOSE: To propose a 3D quantitative high-resolution T1 mapping technique, called 3D SASHA (saturation-recovery single-shot acquisition), which combines a saturation recovery pulse with 1D-navigator-based-respiratory motion compensation to acquire the whole volume of the heart in free breathing. The sequence was tested and validated both in a T1 phantom and in healthy subjects.MATERIALS AND METHODS:The 3D SASHA method was implemented on a 1.5T scanner. A diaphragmatic navigator was used to allow free-breathing acquisition and the images were acquired with a resolution of 1.4 × 1.4 × 8 mm3 . For assessment of accuracy and precision the sequence was compared with the reference gold-standard inversion-recovery spin echo (IRSE) pulse sequence in a T1 phantom, while for the in vivo studies (10 healthy volunteers) 3D SASHA was compared with the clinically used 2D MOLLI (3-3-5) and 2D SASHA protocols.RESULTS:There was good agreement between the T1 values measured in a T1 phantom with 3D SASHA and the reference IRSE pulse sequences (1111.6 ± 31 msec vs. 1123.6 ± 8 msec, P = 0.9947). Mean and standard deviation of the myocardial T1 values in healthy subjects measured with 2D MOLLI, 2D SASHA, and 3D SASHA sequences were 881 ± 40 msec, 1181.3 ± 32 msec, and 1153.6 ± 28 msec respectively.CONCLUSION:The proposed 3D SASHA sequence allows for high-resolution free-breathing whole-heart T1 -mapping with T1 values in good agreement with the 2D SASHA and improved precision.