Pontificia Universidad Católica de Chile Pontificia Universidad Católica de Chile
Poonawalla AH, Sjoberg BP, Rehm JL, Hernando D, Hines CD, Irarrazaval P, Reeder SB. Adipose tissue MRI for quantitative measurement of central obesity. Journal Magnetic Resonance Imaging, vol 37, no 3, 707-716, 2013 (2013)

Adipose tissue MRI for quantitative measurement of central obesity

Volumen : 37
Número : 3
Páginas : 707-716
Tipo de publicación : Publicaciones WOS sin afiliación UC Ir a publicación


Purpose: To validate adipose tissue magnetic resonance imaging (atMRI) for rapid, quantitative volumetry of visceral adipose tissue (VAT) and total adipose tissue (TAT). Materials and Methods: Data were acquired on normal adults and clinically overweight girls with Institutional Review Board (IRB) approval/parental consent using sagittal 6-echo 3D-spoiled gradient-echo (SPGR) (26-sec single-breath-hold) at 3T. Fat-fraction images were reconstructed with quantitative corrections, permitting measurement of a physiologically based fat-fraction threshold in normals to identify adipose tissue, for automated measurement of TAT, and semiautomated measurement of VAT. TAT accuracy was validated using oil phantoms and in vivo TAT/VAT measurements validated with manual segmentation. Group comparisons were performed between normals and overweight girls using TAT, VAT, VAT-TAT-ratio (VTR), body-mass-index (BMI), waist circumference, and waist-hip-ratio (WHR). Results: Oil phantom measurements were highly accurate (<3% error). The measured adipose fat-fraction threshold was 96% +/- 2%. VAT and TAT correlated strongly with manual segmentation (normals r2 0.96, overweight girls r2 0.99). VAT segmentation required 30 +/- 11 minutes/subject (14 +/- 5 sec/slice) using atMRI, versus 216 +/- 73 minutes/subject (99 +/- 31 sec/slice) manually. Group discrimination was significant using WHR (P < 0.001) and VTR (P = 0.004). Conclusion: The atMRI technique permits rapid, accurate measurements of TAT, VAT, and VTR.