Pontificia Universidad Católica de Chile Pontificia Universidad Católica de Chile
Cataldo V.F., López J., Cárcamo M. and Agosin E. (2016)

Chemical vs. biotechnological synthesis of C13-apocarotenoids: current methods, applications and perspectives

Revista : Applied Microbiology and Biotechnology
Volumen : 100
Número : 13
Páginas : 5703-5718
Tipo de publicación : ISI Ir a publicación


Apocarotenoids are natural compounds derived from the oxidative cleavage of carotenoids. Particularly, C13-apocarotenoids are volatile compounds that contribute to the aromas of different flowers and fruits, and are highly valued by the Flavor and Fragrance industry. So far, chemical synthesis of these terpenoids has dominated the industry. Nonetheless, the increasing consumer demand for more natural and sustainable processes raises an interesting opportunity for bio-production alternatives. In this regard, enzymatic biocatalysis and metabolically engineered microorganisms emerge as attractive biotechnological options. The present review summarizes promising bioengineering approaches with regard to chemical production methods for the synthesis of two families of C13-apocarotenoids: ionones/dihydroionones and damascones/damascenone. We discuss each method and its applicability, with a thorough comparative analysis for ionones, focusing on the production process, regulatory aspects and sustainability.