Pontificia Universidad Católica de Chile Pontificia Universidad Católica de Chile
Sahlo F., Cuellar J., Pérez A., Fields A.J., Campos M. and Ramos-Grez J. (2015)

Structural parameters determining the strength of the porcine vertebral body affected by tumours

Revista : Computer Methods in Biomechanics and Biomedical Engineering
Volumen : 18
Número : 8
Páginas : 890-899
Tipo de publicación : ISI Ir a publicación


Spinal metastatic disease could lead to catastrophic consequences for the patient. However, the structural parameters that explain the weakening of vertebrae affected by tumours are not fully understood. In this study, we developed a specimen- specific finite element model to predict the strength of the porcine vertebra with simulated tumours and used it to find the structural parameters determining the strength. We validated our model with mechanical testing and then we analysed the compressive strength of intact vertebrae and seven defects with different size and shape. The results showed that the minimum bone mineral mass of the cross section and areal defect fraction were the best predictors of the normalized strength. We also found that areal parameters appeared to be better predictors than the volumetric ones. In conclusion, reduction in bone strength for vertebrae weakened by metastatic tumours is mostly associated with decrease in the mechanical properties of the cross section.